I hope a dead horse but here goes anyway:

The ball is loose just outside of top of the penalty area, say in the D. And suppose that the ball isn’t moving at all. An attacker is running onto the ball and the only defender, say the keeper runs out and picks up ball outside the penalty area. Can the referee send the keeper off if the referee deems that this action denied an obvious goal scoring OPPORTUNITY?

USSF answer (October 3, 2011):
In the scenario you present, the deliberate handling by the goalkeeper outside his own penalty area, no obvious goalscoring opportunity has been denied. There is no evidence that, but for the handling by the goalkeeper, the ball would have gone into the goal. The horse is dead. Long live the horse.